Vol. 1 No. 1 (2025)

Articles

SLC2A14 In Hepatoblastoma Clinical Significance And Potential Roles In Ferroptosis

Published 2025-01-16

  • Wen Bing Li
    • ,
  • Jing Xiao Li
    • ,
  • Guo Sheng Li
    • ,
  • Gui Yu Feng
    • ,
  • Guan Qiang Yan
    • ,
  • Xiang Gao
    • ,
  • Jun Liu
    • ,
  • Hua Fu Zhou

Wen Bing Li
Department of Hepatobiliary Surgery, The Cancer Hospital of Guangxi Medical Universit

Jing Xiao Li
Department of Thoracic Surgery, The First Affiliated Hospital of Guangxi Medical University

Guo Sheng Li
Department of Hepatobiliary Surgery, The Cancer Hospital of Guangxi Medical University

Gui Yu Feng
Department of Hepatobiliary Surgery, The Cancer Hospital of Guangxi Medical University

Guan Qiang Yan
Department of Hepatobiliary Surgery, The Cancer Hospital of Guangxi Medical University,

Xiang Gao
Department of Hepatobiliary Surgery, The Cancer Hospital of Guangxi Medical University,

Jun Liu
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University

Hua Fu Zhou
Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University

Abstract

The study aimed to investigate the role of SLC2A14 in hepatoblastomaHB,a prevalent pediatric liver tumor.Through RNA-seq analysis of public and in-house datasets,we found SLC2A14 upregulated in HB and linked to ferroptosis.Our analysis revealed SLC2A14s potential as a diagnostic marker and its association with tumor metabolism,suggesting it may be a therapeutic target.The study concludes that SLC2A14s role in HB should be further explored for clinical applications.

Keywords

Hepatoblastoma,SLC2A14,Ferroptosis,GLUT Family,Pediatric Oncology,Tumor Metabolism

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